After a breakthrough Grand Slam at Wimbledon, where he lost in the semi-finals to Marin Cilic, Querrey won the title at Los Cabos in Mexico (his second of 2017) to start off the North American hardcourt season.
Fourth seed Alexander Zverev was one of the favourites to win the US Open title before the tournament started, but it's his brother Mischa who has outlasted him at a Major for the second time in the year.
Italy's Paolo Lorenzi, 35, became the oldest player in the Open Era to reach a Grand Slam last 16 for the first time by defeating countryman Thomas Fabbiano 6-2, 6-4, 6-4.
An open bottom half of the men's bracket means it's hard to predict who will advance to the final, but Cilic-the highest seed in that half-looks likely to be a major favourite.
Shapovalov converted four of 13 break points and committed 32 unforced errors to Edmund's 24.
Mahut, ranked 115th, is best known for losing the longest match in tennis history, 70-68 in the fifth set against John Isner at Wimbledon in 2010.
Garbine Muguruza will have her eyes set on the U.S. Open crown in NY after seeing some of the women's favourites drop out early, and she will face Magdalena Rybarikova for a fourth-round spot on Friday. When I served 5-2, I think he played much better than me. Straight set wins over Berlocq and Tipsarevic seeing him reach the third round in NY for the first time.
Schwartzman played far from a flawless match, committing 48 unforced errors and almost squandering a double-break lead in the fourth set, but he hung on to win in three hours and 23 minutes.
He dropped the first set against his opponent, Kyle Edmund, but hit back to take the next two sets before the Brit pulled the pin early in the fourth due to injury.
Energy Secretary Rick Perry taps emergency oil reserve in wake of Harvey
Data next week will provide a better indication of the extent of the damage to the USA energy sector from Tropical Storm Harvey. If it drops below $40, producers may not be able to make a profit, and drilling new wells would likely taper off, she said.
Five women still remain in contention for the No. 1 ranking as the U.S. Open's third round begins.
Two of the others, current No. 1 Karolina Pliskova and Elina Svitolina, will play Saturday.
Sharapova, the 2006 US Open victor, has already beaten Halep and Hungary's Timea Babos in her first Grand Slam since serving a 15-month doping ban after testing positive for the blood booster meldonium, at the 2016 Australian Open.
Action is underway on Day 5, with two-time Wimbledon champion Petra Kvitova facing 18th-seeded Caroline Garcia in Arthur Ashe Stadium.
Williams faces Greece's Maria Sakkari and is hoping to make the competition's fourth round for the third year in succession; a home crowd is sure to have its advantages for the 37-year-old. The Tennis Channel will be running a preview show between 8 a.m. -11 a.m. ET, along with replays through the days and nights of the tournament.
The Argentine, seeded 29th, broke Cilic nine times while delivering a huge upset over the 2014 U.S. Open champ.
Petra Kvitova, of the Czech Republic, returns a shot from Caroline Garcia, of France, during the third round of the U.S. Open tennis tournament, Friday, Sept. 1, 2017, in NY.
Caroline Garcia, of France, returns a shot from Petra Kvitova, of the Czech Republic, during the third round of the U.S. Open tennis tournament, Friday, Sept. 1, 2017, in NY.
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