Bolt, anchoring the team, pulled up and fell to the ground in agony as there was no heartwarming ending to his athletics career.
The Jamaican quartet of Tyquendo Tracey, Julian Forte, Micheal Campbell and Bolt led the eight-team second heat from beginning to the end.
And who can forget Justin Gatlin, who has served two drugs bans, upstaging Usain Bolt in his individual 100m swansong a week ago and all the boos that followed.
Turning to the ongoing World Championships, Coe said it was quite a shock for some to see Usain Bolt finish third in the 100m sprint even though he was not very surprised.
The top three from each of the two heats and next two fastest finishers from the remaining qualify for the final round.
The four - the same line-up who won Team GB's first 4x100m relay bronze in 32 years in Rio last summer - crossed the line 0.09 seconds behind the U.S., with Germany qualifying as third fastest.
Jamaica clocked the third quickest time in the heats, behind the US and Great Britain.
It was the first time Bolt had lost a World Championships 100m final he had started, having been disqualified for a false start in Daegu in 2011. "We've been battling for years and he finally got one (gold); yes it's at the end of my career but I have to show respect and where respect is due", added the Jamaican, who insisted his legacy remains intact.
This time, it was Gatlin doing the passing, and now he is a world champion in addition to a trivia question: Who was the last sprinter to win Olympic gold in the 100 before Bolt?
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Since then he has dominated the shorter two sprint events like none in athletics history.
The Olympics, held every four years, and the World Championships, held every other year, are the premier attractions in track and field and are viewed almost equally on the global stage. What's more, Gatlin denies him the crutch of old age, which Bolt could have leaned on to justify his retirement and/or rationalize this loss. He did his routine marking of his starting position and did a few run-downs imitating baton exchange. Bolt routinely slowed down before crossing the finish line.
"There are no words to describe how I am feeling. I came out and did the best I could".
"I did a lot of practice here in the past 10 days to break the national record. It's hard to be sad, the energy, the vibe here, it's been brilliant".
Nearly all of Bolt's money comes from endorsements, including deals with Puma, Sprint, and Advil, Forbes says. He wants to run in the final and has been taking part in relay training here. Still there were some mistakes.
Yohan Blake of Jamaica at the World Athletics Championship 2017 in London, August 12, 2017.
Usain Bolt will run in the 4x100m qualifying at the World Championships, with the possibility of going on to the final.
The United States, featuring 100m champion Justin Gatlin, will provide the biggest danger in their aim to win the event for a first time in ten years.
Defending champions Jamaica (42.50) finished second behind Germany (42.34) in the second heat.
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